Corticosteroids in Septic Shock with Dr. Jerry Zimmerman Part 2

Jerry Zimmerman, M.D, PhD, FCCM is a Professor of Pediatrics at the University of Washington and the former Chief of the Division of Critical Care Medicine and the Director of the Pediatric Intensive Care Unit at Seattle Children’s Hospital. He is a past president of the Society of Critical Care Medicine. Dr. Zimmerman is the co-editor of the textbook Pediatric Critical Care and is an accomplished researcher. He was a charter principal investigator in the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) network and is a co-principal investigator for the Stress Hydrocortisone in Pediatric Septic Shock (SHIPSS) trial that we will discuss later in this episode. 

Learning Objectives:

By the end of this podcast, listeners should be able to discuss:

1. The physiologic rationale supporting and opposing the use of corticosteroids in septic shock.
2. The high-quality clinical evidence supporting and opposing the use of corticosteroids in septic shock.
3. The current practice patterns among pediatric intensivists in prescribing corticosteroids in septic shock.
4. The clinically relevant side effects associated with corticosteroids in septic shock.
5. Future research of corticosteroids in septic shock with emphasis on the Stress Hydrocortisone in Pediatric Septic Shock (SHIPSS) study.

Key reference:

Zimmerman, Jerry J. MD, PhD, FCCM. A history of adjunctive glucocorticoid treatment for pediatric sepsis: Moving beyond steroid pulp fiction toward evidence-based medicine. Pediatric Critical Care Medicine: November 2007 - Volume 8 - Issue 6 - p 530-539

Other references: 

 PMID: 32058370 
 PMID: 20228689 
 PMID: 29979221 
 PMID: 29490185 
 PMID: 29347874 
 PMID: 27695824 
 PMID: 18184957 
 PMID: 12186604