Scaling US Pathogen Detection

Audio versions of blogs and papers from BlueDot courses. 

Description: This post models how an effective biosurveillance system might work in the US using metagenomic sequencing (MGS). Metagenomic sequencing can read out any nucleic acid (RNA or DNA) in a sample. Analyzing these fragments allows the identification of both known pathogens as well as unknown reads that could represent a new threat. 

Original Text: https://naobservatory.org/blog/biothreat_radar/

Author(s): Simon Grimm, Lennart Justen, and Jeff Kaufman. 

A podcast by BlueDot Impact.

Chapters

• 0:17 Summary
• 1:02 Structure and cost of an advanced biosurveillance system
• 1:08 Overall structure
• 3:02 Overall cost
• 4:42 Collection
• 8:21 Processing
• 9:11 Analysis and threat detection
• 10:34 Pathogen detection performance
• 13:39 Monitoring
• 14:07 Discovery
• 15:35 Features needed for optimal performance
• 20:11 Conclusion