Inside Lyme Podcast with Dr. Daniel Cameron
You are listening to a show dedicated to discussing actual cases. Dr. Cameron has been treating adolescents and adults with Lyme disease and related tick-borne infections for more than 30 years. The advice given is general and not intended as specific advice as to any particular patient. If you require specific advice, you will need to seek that advice from an experienced professional.
Inside Lyme Podcast with Dr. Daniel Cameron
Why Stopping Lyme Treatment Too Soon Can Backfire
Have you had symptoms return after stopping Lyme treatment? Share your story below. Your experience may help someone else navigating the same difficult decision.
Summary
One of the most frequent questions in Lyme care is: “If I feel better, should I stop treatment?” The answer is complicated. While no one wants to stay on antibiotics longer than necessary, stopping too soon often leads to relapse.
Lyme disease is not a typical infection. Borrelia burgdorferi can persist by hiding in tissues, forming biofilms, and shifting into alternate forms. When treatment ends prematurely, surviving bacteria may re-emerge, and symptoms such as brain fog, joint pain, fatigue, or neuropathy often return. Co-infections like Babesia or Bartonella add another layer, sometimes becoming more obvious once Lyme therapy is withdrawn.
Guidelines remain divided. IDSA discourages extended therapy, while ILADS—where I helped author the 2004 and 2014 guidelines—supports individualized, carefully monitored treatment when patients remain ill. The key is shared decision-making, weighing risks and benefits, and avoiding a one-size-fits-all approach.
The goal is not indefinite treatment, but the minimum effective therapy that allows patients to heal and reclaim their lives. The takeaway is simple: stopping Lyme treatment too soon often means starting over. Recovery is about staying better tomorrow—not just feeling better today.