Alexander Disease Research Update - Episode #12: GFAP variants and oxidative stress/mitochondrial dysfunction; commentary on dizziness, risks of brain biopsies

Albee Messing, Rachel Battaglia, and Abby Olsen discuss the following recent publication: 

[01:00]        Alexander disease GFAP R239C mutant shows increased susceptibility to lipoxidation and elicits mitochondrial dysfunction and oxidative stress (Redox Biology, 55:102415, 2022)

[14:23]       Questions from email regarding 1) dizziness and 2) risks of brain biopsies. 

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Chapters

• 1:01 Alexander disease GFAP R239C mutant shows increased susceptibility to lipoxidation and elicits mitochondrial dysfunction and oxidative stress
• 14:23 Questions