Alexander Disease Research Update
Discussion of recent publications from the research literature on Alexander Disease, hosted by Albee Messing from the University of Wisconsin-Madison.
Alexander Disease Research Update
Alexander Disease Research Update – Episode #32: 1) GFAP variants and oxidative stress, and 2) GFAP variants and lysosomes
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Albee Messing, Dolores Pérez-Sala, and Natasha Snider discuss the following recent publications:
Alexander disease mutations differentially sensitize glial fibrillary acidic protein (GFAP) to posttranslational modifications and network disruption by oxidants.
Redox Biology 92:104103 (2026)
Lysosomal function, resistance to oxidative stress and repair are compromised by expression of the Alexander disease GFAP R239C mutant.
Free Radical Biology & Medicine (in press)
Send your questions and feedback to: amessing@wisc.edu
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https://alexander-disease.waisman.wisc.edu/donate/
Podcasts are supported by Daniel's Fight (https://www.danielsfight.com)